In-silico drug designing has become an important trend for some good reasons- first it cuts down drug designing lag time to a great extent and second it saves a significant sum of money invested for the process. Docking macromolecules to small ligands constitutes the central theme of this process and this in many ways is analogous to the conventional target based drug designing concept. However, unlike cell based therapy it is only limited to specific targets which are in most case protein molecules. Here, in this manuscript two studies of docking have been elucidated. Two small molecules, sissotrin and silibin, have been bound exhaustively to many shortlisted targets of them and screened for maximum score values to hypothesize one potential target macromolecule. PDGFR, ALOX5 and IGFBP3 are the the found targets from the research works. The small molecules taken here are found in traditional sources such as herbal plants. Therefore outcomes from this research is expected to underpin importance of these natural resources that are regaining prominence worldwide for their drug activity. Nonetheless, these studies have to further be validated in-vitro for concrete proof in the future.
Whether you're the project manager for your company's rebrand, or you need to educate your staff or your students about brand fundamentals, Designing Brand Identity is the quintessential resource. From research to brand strategy to design execution, launch, and governance, Designing Brand Identity is a compendium of tools for branding success and best practices for inspiration. 3 sections: brand fundamentals, process basics, and case studies. Over 100 branding subjects, checklists, tools, and diagrams. 50 case studies that describe goals, process, strategy, solution, and results. Over 700 illustrations of brand touchpoints. More than 400 quotes from branding experts, CEOs, and design gurus. «Designing Brand Identity is a comprehensive, pragmatic, and easy-to-understand resource for all brand builders—global and local. It's an essential reference for implementing an entire brand system.» – Carlos Martinez Onaindia, Global Brand Studio Leader, Deloitte «Alina Wheeler explains better than anyone else what identity design is and how it functions. There's a reason this is the 5th edition of this classic.» – Paula Scher, Partner, Pentagram «Designing Brand Identity is the book that first taught me how to build brands. For the past decade, it's been my blueprint for using design to impact people, culture, and business.» – Alex Center, Design Director, The Coca-Cola Company «Alina Wheeler's book has helped so many people face the daunting challenge of defining their brand.» – Andrew Ceccon, Executive Director, Marketing, FS Investments «If branding was a religion, Alina Wheeler would be its goddess, and Designing Brand Identity its bible.» – Olka Kazmierczak, Founder, Pop Up Grupa «The 5th edition of Designing Brand Identity is the Holy Grail. This book is the professional gift you have always wanted.» – Jennifer Francis, Director of Marketing, Communications, and Visitor Experience, Louvre Abu Dhabi
Innovation in planning is essential to dealing with the challenges society currently faces, from urban sprawl to climate change. In this book, Avi Friedman looks at both new and revived sustainable strategies at a neighborhood level to explore options for both rehabilitating older communities as well as options for those projects being designed from scratch. The book takes a holistic approach to sustainable community design, covering aspects such as: - Transportation and how to avoid reliance on private vehicles - Ecological, psychological and economic values of open spaces - Neighborhood resilience and health - Affordability and energy consumption Interviews with and information from designers of sustainable communities provide first-hand insight into their development. Outstanding illustrated case studies from communities throughout the world add depth and insight into this important subject.
The book is written to fill the gap of available information and study materials available on ecotourism.It is prepared to help the emerging tourism professional and students as well as faculties to provide them supporting materials, case studies and examples. The book contains a simplicity in diversity and touches almost all the important issues and points which is required to understand the concept of ecotourism and further leads to advance stage that is ecotourism principles,Approach, wildlife and tourism economics, ecotourism and wildlife project designing, planning and ends with adaptive management techniques. It includes various case studies and perceptions of eminent authors and scholars. It highlights the importance of various forms of ecotourism that helps in sustainable growth and development of village, region, state and country. It also covers the protected areas management ,visitors management, conservation and preservation of wildlife and natural resources, tourism demand and supply analysis, demand forecasting, carrying capacity of sites,and other issues. This is an effective ecotourism manual for aspiring tourism professional.